Sakamoto Ryoko, Higashi Yuko, Mera Kentaro, Kanekura Takuro, Kanzaki Tamotsu
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
J Dermatol. 2006 Jan;33(1):43-5. doi: 10.1111/j.1346-8138.2006.00008.x.
Leuprorelin acetate, a chemotherapeutic agent used to treat prostate cancer, is a synthetic luteinizing hormone-releasing hormone (LHRH) agonist. We report a 75-year-old man who presented with several large subcutaneous nodules at the site of leuprorelin acetate injections for his prostatic cancer. A biopsy of the nodules disclosed epithelioid granulomatous inflammation and resulted in a diagnosis of drug-induced granulomatous reaction to leuprorelin acetate.
醋酸亮丙瑞林是一种用于治疗前列腺癌的化疗药物，是一种合成的促黄体生成激素释放激素（LHRH）激动剂。我们报告一名75岁男性，他在接受醋酸亮丙瑞林注射治疗前列腺癌的部位出现了几个大的皮下结节。对这些结节进行活检发现有上皮样肉芽肿性炎症，最终诊断为对醋酸亮丙瑞林的药物性肉芽肿反应。
