Division of Musculoskeletal Radiology, Department of Radiology, Duke University Medical Center, DUMC Box 3808, Durham, NC 27710, USA.
Skeletal Radiol. 2012 Mar;41(3):347-52. doi: 10.1007/s00256-011-1254-8. Epub 2011 Aug 23.
Leuprorelin is a luteinizing hormone-releasing hormone (LH-RH) agonist that is used as an agent of androgen deprivation in some patients with prostate cancer. When administered in depot form, local granulomatous reactions may occur at the injection site, which may mimic masses and which are associated with treatment failure. We present a patient who, over a period of 5 years, developed multiple intramuscular gluteal masses while receiving leuprorelin therapy via intramuscular depot injections; biopsy of one of the masses showed the specific histologic features of leuprorelin granuloma. To our knowledge, this entity has not been described in the radiology literature. Awareness of this entity is necessary to suggest the correct diagnosis in patients with a history of leuprorelin depot injections.
亮丙瑞林是一种促黄体生成素释放激素（LH-RH）激动剂，在某些前列腺癌患者中被用作雄激素剥夺治疗的药物。当以储库形式给药时，可能会在注射部位发生局部肉芽肿反应，这些反应可能类似于肿块，并与治疗失败有关。我们介绍了一位患者，他在接受肌肉内储库注射亮丙瑞林治疗的 5 年内，多个臀部肌肉内出现肿块；对其中一个肿块的活检显示出亮丙瑞林肉芽肿的特定组织学特征。据我们所知，该实体尚未在放射学文献中描述。对于有亮丙瑞林储库注射史的患者，了解该实体对于提示正确诊断是必要的。
