Visvanathan Renuka, Horowitz Michael, Chapman Ian
Department of Medicine, University of Adelaide, Adelaide, South Australia.
Br J Nutr. 2006 Feb;95(2):340-5. doi: 10.1079/bjn20051633.
The objective of the present study was to determine the comparative hypotensive responses to drinks containing predominantly fat and carbohydrate (CHO) in healthy elderly subjects. Using a randomised, cross-over study, the participants, twelve elderly subjects, six of them female (72.2 (sd 5.7) years), were investigated. On three separate days, blood pressure (BP) and heart rate were measured following ingestion of 300 ml drinks containing: (1) CHO (75 g glucose and 93 g Polyjoule (CHO polymer) providing 2732 kJ (653 kcal)); (2) 88 % fat (cream blended with milk providing 2732 kJ (653 kcal)); (3) water. Systolic BP decreased following the CHO drink (P<0.001) and the high-fat drink (P<0.001) but not water; there was no difference in the magnitude of the decrease between the CHO drink and the drink containing fat (13.4 v. 15.6 mmHg). However, the onset of the fall was slower after the fat-containing drink (13.0 v. 26.5 min (P=0.01); area under the curve for 0-30 min for CHO drink -6.5 v. fat-containing drink 125.4 mmHg x min (P=0.043)). We conclude that ingestion of a high-fat drink results in a comparable fall in BP to a CHO drink although the onset is relatively slower. These observations may have implications for the management of postprandial hypotension.
本研究的目的是确定健康老年受试者对主要含脂肪和碳水化合物（CHO）饮料的降压反应比较。采用随机交叉研究，对12名老年受试者（其中6名女性，年龄72.2（标准差5.7）岁）进行了调查。在三个不同的日子里，受试者摄入300毫升饮料后测量血压（BP）和心率，这些饮料分别为：（1）CHO（75克葡萄糖和93克聚焦耳（CHO聚合物），提供2732千焦（653千卡））；（2）88%脂肪（奶油与牛奶混合，提供2732千焦（653千卡））；（3）水。饮用CHO饮料（P<0.001）和高脂饮料后收缩压下降，但饮水后未下降；CHO饮料和含脂肪饮料的下降幅度没有差异（13.4对15.6毫米汞柱）。然而，含脂肪饮料后血压下降的起始较慢（13.0对26.5分钟（P=0.01）；CHO饮料0-30分钟曲线下面积为-6.5，含脂肪饮料为125.4毫米汞柱×分钟（P=0.043））。我们得出结论，饮用高脂饮料导致的血压下降幅度与CHO饮料相当，尽管起始相对较慢。这些观察结果可能对餐后低血压的管理有影响。
