Jiang Hong, Delgado Silvia, Tan Jia, Liu Che, Rammohan Kottil W, DeBuc Delia Cabrera, Lam Byron L, Feuer William J, Wang Jianhua
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA/Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA
Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
Mult Scler. 2016 Dec;22(14):1812-1820. doi: 10.1177/1352458516631035. Epub 2016 Feb 22.
The transparent ocular structure enables quantitative analysis of microvasculature of retina, a neuronal tissue affected by multiple sclerosis (MS).
The aim of this study was to determine whether the retinal blood flow velocity and flow volume at the macula are impaired in patients with relapsing remitting multiple sclerosis (RRMS).
A total of 17 RRMS patients and 17 age- and gender-matched healthy subjects were assessed. A retinal function imager was used to measure the blood flow velocity of retinal arterioles and venules and to calculate the total perifoveal blood flow volume.
The blood flow velocities of the retinal arterioles (3.34 ± 0.89 mm/s) and venules (2.61 ± 0.6 mm/s) were significantly lower in MS patients than normal subjects (arteriole: 4.10 ± 0.87 mm/s; venule: 3.22 ± 0.65 mm/s, both p = 0.01). In addition, the total perifoveal blood flow volume in arterioles (3.74 ± 1.64 nL/s) and venules (3.81 ± 1.60 nL/s) were significantly lower in MS patients than in normal subjects (arteriole: 4.87 ± 1.41 nL/s, p = 0.02; venule: 4.71 ± 1.64 nL/s, p = 0.04).
The impaired retinal microcirculation in RRMS patients indicates microvascular dysfunction in MS.
透明的眼部结构能够对视网膜的微血管进行定量分析，视网膜是受多发性硬化症（MS）影响的神经组织。
本研究旨在确定复发缓解型多发性硬化症（RRMS）患者黄斑区的视网膜血流速度和血流量是否受损。
共评估了17例RRMS患者和17例年龄及性别匹配的健康受试者。使用视网膜功能成像仪测量视网膜小动脉和小静脉的血流速度，并计算中央凹周围的总血流量。
MS患者视网膜小动脉（3.34±0.89mm/s）和小静脉（2.61±0.6mm/s）的血流速度显著低于正常受试者（小动脉：4.10±0.87mm/s；小静脉：3.22±0.65mm/s，p均=0.01）。此外，MS患者小动脉（3.74±1.64nL/s）和小静脉（3.81±1.60nL/s）的中央凹周围总血流量显著低于正常受试者（小动脉：4.87±1.41nL/s，p=0.02；小静脉：4.71±1.64nL/s，p=0.04）。
RRMS患者视网膜微循环受损表明MS存在微血管功能障碍。
