Halton Thomas L, Willett Walter C, Liu Simin, Manson Joann E, Stampfer Meir J, Hu Frank B
Department of Nutrition and Epidemiology, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02215, USA.
Am J Clin Nutr. 2006 Feb;83(2):284-90. doi: 10.1093/ajcn/83.2.284.
Potatoes, a high glycemic form of carbohydrate, are hypothesized to increase insulin resistance and risk of type 2 diabetes.
The objective was to examine prospectively the relation between potato consumption and the risk of type 2 diabetes.
We conducted a prospective study of 84,555 women in the Nurses' Health Study. At baseline, the women were aged 34-59 y, had no history of chronic disease, and completed a validated food-frequency questionnaire. The participants were followed for 20 y with repeated assessment of diet.
We documented 4496 new cases of type 2 diabetes. Potato and french fry consumption were both positively associated with risk of type 2 diabetes after adjustment for age and dietary and nondietary factors. The multivariate relative risk (RR) in a comparison between the highest and the lowest quintile of potato intake was 1.14 (95% CI: 1.02, 1.26; P for trend = 0.009). The multivariate RR in a comparison between the highest and the lowest quintile of french fry intake was 1.21 (95% CI: 1.09, 1.33; P for trend < 0.0001). The RR of type 2 diabetes was 1.18 (95% CI: 1.03, 1.35) for 1 daily serving of potatoes and 1.16 (95% CI: 1.05, 1.29) for 2 weekly servings of french fries. The RR of type 2 diabetes for substituting 1 serving potatoes/d for 1 serving whole grains/d was 1.30 (95% CI: 1.08, 1.57). The association between potato consumption and risk of type 2 diabetes was more pronounced in obese women.
Our findings suggest a modest positive association between the consumption of potatoes and the risk of type 2 diabetes in women. This association was more pronounced when potatoes were substituted for whole grains.
土豆是一种高血糖生成指数的碳水化合物，据推测会增加胰岛素抵抗和2型糖尿病风险。
前瞻性研究土豆摄入量与2型糖尿病风险之间的关系。
我们在护士健康研究中对84555名女性进行了一项前瞻性研究。在基线时，这些女性年龄在34至59岁之间，无慢性病病史，并完成了一份经过验证的食物频率问卷。对参与者进行了20年的随访，并反复评估饮食情况。
我们记录了4496例新的2型糖尿病病例。在调整年龄、饮食和非饮食因素后，土豆和薯条的摄入量均与2型糖尿病风险呈正相关。土豆摄入量最高五分位数与最低五分位数相比的多变量相对风险（RR）为1.14（95%CI：1.02，1.26；趋势P值=0.009）。薯条摄入量最高五分位数与最低五分位数相比的多变量RR为1.21（95%CI：1.09，1.33；趋势P值<0.0001）。每天食用1份土豆时，2型糖尿病的RR为1.18（95%CI：1.03，1.35），每周食用2份薯条时，RR为1.16（95%CI：1.05，1.29）。用每天1份土豆替代1份全谷物时，2型糖尿病的RR为1.30（95%CI：1.08，1.57）。在肥胖女性中，土豆摄入量与2型糖尿病风险之间的关联更为明显。
我们的研究结果表明，女性土豆摄入量与2型糖尿病风险之间存在适度的正相关。当用土豆替代全谷物时，这种关联更为明显。
