Kubota Reiji, Kunito Takashi, Agusa Tetsuro, Fujihara Junko, Monirith In, Iwata Hisato, Subramanian Annamalai, Tana Touch Seang, Tanabe Shinsuke
Center for Marine Environmental Studies, Ehime University, Bunkyo-cho 2-5, Matsuyama 790-8577, Japan.
J Environ Monit. 2006 Feb;8(2):293-9. doi: 10.1039/b513652k. Epub 2005 Dec 15.
Arsenic concentrations in hair and urine, and urinary levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, were examined for inhabitants of the Mekong Basin in Kratie Province, Cambodia. Also, the arsenic levels of tube-well water were determined. Total arsenic concentrations in tube-well water ranged from <1 to 886 microg L(-1), and 44.8% of these exceeded the WHO drinking water guideline of 10 microg L(-1). Elevated levels of arsenic were observed in the human hair and urine, and also a significant positive correlation was observed between the concentrations in hair and urine. These results suggest that the inhabitants are chronically exposed to arsenic through drinking the tube-well water. Levels of urinary 8-OHdG were higher for the subjects with higher arsenic levels in hair and urine, suggesting that induction of oxidative DNA damage was caused by chronic exposure to arsenic in tube-well water for the inhabitants in Kratie Province. To our knowledge, this is the first report on the oxidative DNA damage caused by chronic exposure to arsenic in groundwater for the inhabitants in Cambodia.
对柬埔寨桔井省湄公河流域的居民，检测了其头发和尿液中的砷浓度，以及作为氧化DNA损伤标志物的尿8-羟基-2'-脱氧鸟苷（8-OHdG）水平。同时，测定了管井水的砷含量。管井水中总砷浓度范围为<1至886微克/升，其中44.8%超过了世界卫生组织10微克/升的饮用水准则。在人体头发和尿液中观察到砷水平升高，并且头发和尿液中的浓度之间存在显著正相关。这些结果表明，居民通过饮用管井水长期接触砷。头发和尿液中砷水平较高的受试者尿8-OHdG水平也较高，这表明桔井省居民长期接触管井水中的砷会导致氧化DNA损伤。据我们所知，这是关于柬埔寨居民长期接触地下水中的砷导致氧化DNA损伤的首份报告。
