Department of Statistics, Acharya Prafulla Chandra College, Kolkata, West Bengal, 700131, India.
School of Environmental Studies, Jadavpur University, Kolkata, 700032, India.
Environ Geochem Health. 2018 Dec;40(6):2359-2369. doi: 10.1007/s10653-018-0102-3. Epub 2018 Mar 26.
Skin lesion is one of the important health hazards caused by high intake of arsenic through drinking water and diet, and the other hazards include several types of cancers (viz. skin, lung and urinary bladder), ischemic heart disease, hypertension, etc. Two most important biomarkers to measure arsenic intake in a human body are arsenic concentration in urine and hair. The primary interest of this paper is the association between skin lesion and arsenic concentration in hair for participants with chronic arsenic exposure from West Bengal, India, using bivariate regression model based on copula function. The result showed participants with high arsenic concentration in hair had higher incidence of developing skin lesion. Arsenic concentration in hair was significantly higher for the participants with an arsenic concentration in water > 10 mg/L.
皮肤损伤是由于饮用水和饮食中摄入过量砷而导致的重要健康危害之一，其他危害包括多种癌症（即皮肤癌、肺癌和膀胱癌）、缺血性心脏病、高血压等。衡量人体砷摄入量的两个最重要的生物标志物是尿液和头发中的砷浓度。本文主要关注的是来自印度西孟加拉邦的慢性砷暴露参与者的皮肤损伤与头发中砷浓度之间的关系，使用基于 copula 函数的二元回归模型。结果表明，头发中砷浓度较高的参与者皮肤损伤的发病率更高。水中砷浓度>10mg/L 的参与者头发中的砷浓度明显更高。
