[中国3岁以上人群乙型肝炎血清流行病学研究]

[A study on the sero-epidemiology of hepatitis B in Chinese population aged over 3-years old].

作者信息

Liang Xiao-feng, Chen Yuan-sheng, Wang Xiao-jun, He Xiong, Chen Li-juan, Wang Jun, Lin Chang-ying, Bai Hu-qun, Yan Jun, Cui Gang, Yu Jing-jin

机构信息

Chinese Center for Disease Control and Prevention, Beijing 100050, China.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2005 Sep;26(9):655-8.

PMID:16471211

Abstract

OBJECTIVE

To better understand and measure the impact from immunization activities over the last 10-years, we conducted a sero-epidemiological study using the remaining blood samples of a nationwide survey on Nutrition and Health in Chinese residents, in 2002.

METHODS

HBsAg, anti-HBs and anti-HBc in blood samples were tested using enzyme-linked immunosorbent assay(ELISA) reagents and revised by solid phase radioimmunoassay and Abbott ELISA reagents.

RESULTS

Among population older than 3 years, the prevalence rates of HBsAg, anti-HBs and hepatitis B virus(HBV) infection were 9.09%, 37.48% and 50.04% but for children between 3 and 12 year olds, they were 5.03%, 45.33% and 29.10% respectively. Among population older than 3 years, the rates of HBsAg and HBV infection in urban area were 4.61% and 43.51%, but the rates in rural area were 9.41% and 56.77% respectively while for children from 3-years to 12-years old, they rates were 2.10%, 20.45% in urban area and 8.25%, 39.22% in rural areas, respectively.

CONCLUSION

Results revealed that since the hepatitis B vaccine was introduced into the expanded program on immunization(EPI) from 1992, the prevalence rates of HBsAg and HBV infection, especially in the children from 3 to 12 years of age, had obviously declined, suggesting that some changes had happened in the epidemic characters of hepatitis B in China.

摘要

目的

为了更好地理解和衡量过去10年免疫接种活动的影响，我们利用2002年全国居民营养与健康调查剩余的血样进行了一项血清流行病学研究。

方法

使用酶联免疫吸附测定（ELISA）试剂检测血样中的乙肝表面抗原（HBsAg）、乙肝表面抗体（抗-HBs）和乙肝核心抗体（抗-HBc），并通过固相放射免疫测定和雅培ELISA试剂进行校正。

结果

在3岁以上人群中，HBsAg、抗-HBs和乙肝病毒（HBV）感染的患病率分别为9.09%、37.48%和50.04%，而在3至12岁儿童中，患病率分别为5.03%、45.33%和29.10%。在3岁以上人群中，城市地区HBsAg和HBV感染率分别为4.61%和43.51%，农村地区分别为9.41%和56.77%，而在3至12岁儿童中，城市地区感染率分别为2.10%、20.45%，农村地区分别为8.25%、39.22%。