一例上唇血管淋巴样增生伴嗜酸性粒细胞增多症（ALHE）。

A case of angiolymphoid hyperplasia with eosinophilia (ALHE) of the upper lip.

作者信息

Suzuki Hiromi, Hatamochi Atsushi, Horie Masaki, Suzuki Toshihiro, Yamazaki Soji

机构信息

Department of Dermatology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan.

出版信息

J Dermatol. 2005 Dec;32(12):991-5. doi: 10.1111/j.1346-8138.2005.tb00888.x.

DOI:10.1111/j.1346-8138.2005.tb00888.x

PMID:16471464

Abstract

Angiolymphoid hyperplasia with eosinophilia (ALHE) is clinically characterized by intradermal or subcutaneous papules and/or nodules usually occurring in young adults. Lesions in the oral mucosa are extremely rare. We report a case and review the literature of ALHE cases involving the oral mucosa. A 40-year-old man presented with a painless, 20 x 20 mm, submucosal nodule on the upper lip. Histological examination of lip biopsy specimens revealed an increase in many small vessels. The vascular walls consisted of prominent endothelial cells with a histiocytoid appearance, which protruded into the lumen. Many eosinophils and lymphocytes were also seen around the vessels. The diagnosis of ALHE was made from the above findings.

摘要

嗜酸性粒细胞增多性血管淋巴样增生（ALHE）的临床特征为真皮内或皮下丘疹和/或结节，通常发生于年轻人。口腔黏膜病变极为罕见。我们报告1例病例，并回顾涉及口腔黏膜的ALHE病例的文献。一名40岁男性患者上唇出现一个无痛性、大小为20×20 mm的黏膜下结节。唇部活检标本的组织学检查显示许多小血管增多。血管壁由突出的、呈组织细胞样外观的内皮细胞组成，这些内皮细胞突入管腔。血管周围还可见许多嗜酸性粒细胞和淋巴细胞。根据上述发现作出了ALHE的诊断。