Suzuki Hiromi, Hatamochi Atsushi, Horie Masaki, Suzuki Toshihiro, Yamazaki Soji
Department of Dermatology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan.
J Dermatol. 2005 Dec;32(12):991-5. doi: 10.1111/j.1346-8138.2005.tb00888.x.
Angiolymphoid hyperplasia with eosinophilia (ALHE) is clinically characterized by intradermal or subcutaneous papules and/or nodules usually occurring in young adults. Lesions in the oral mucosa are extremely rare. We report a case and review the literature of ALHE cases involving the oral mucosa. A 40-year-old man presented with a painless, 20 x 20 mm, submucosal nodule on the upper lip. Histological examination of lip biopsy specimens revealed an increase in many small vessels. The vascular walls consisted of prominent endothelial cells with a histiocytoid appearance, which protruded into the lumen. Many eosinophils and lymphocytes were also seen around the vessels. The diagnosis of ALHE was made from the above findings.
嗜酸性粒细胞增多性血管淋巴样增生（ALHE）的临床特征为真皮内或皮下丘疹和/或结节，通常发生于年轻人。口腔黏膜病变极为罕见。我们报告1例病例，并回顾涉及口腔黏膜的ALHE病例的文献。一名40岁男性患者上唇出现一个无痛性、大小为20×20 mm的黏膜下结节。唇部活检标本的组织学检查显示许多小血管增多。血管壁由突出的、呈组织细胞样外观的内皮细胞组成，这些内皮细胞突入管腔。血管周围还可见许多嗜酸性粒细胞和淋巴细胞。根据上述发现作出了ALHE的诊断。
