Lehmann Christoph, Herdener Marcus, Esposito Fabrizio, Hubl Daniela, di Salle Francesco, Scheffler Klaus, Bach Dominik R, Federspiel Andrea, Kretz Robert, Dierks Thomas, Seifritz Erich
University Hospital of Clinical Psychiatry, University of Bern, 3000 Bern, Switzerland.
Neuroimage. 2006 May 15;31(1):294-300. doi: 10.1016/j.neuroimage.2005.12.038. Epub 2006 Feb 9.
The auditory cortex is anatomically segregated into a central core and a peripheral belt region, which exhibit differences in preference to bandpassed noise and in temporal patterns of response to acoustic stimuli. While it has been shown that visual stimuli can modify response magnitude in auditory cortex, little is known about differential patterns of multisensory interactions in core and belt. Here, we used functional magnetic resonance imaging and examined the influence of a short visual stimulus presented prior to acoustic stimulation on the spatial pattern of blood oxygen level-dependent signal response in auditory cortex. Consistent with crossmodal inhibition, the light produced a suppression of signal response in a cortical region corresponding to the core. In the surrounding areas corresponding to the belt regions, however, we found an inverse modulation with an increasing signal in centrifugal direction. Our data suggest that crossmodal effects are differentially modulated according to the hierarchical core-belt organization of auditory cortex.
听觉皮层在解剖学上分为中央核心区和外周带区，这两个区域在对带通噪声的偏好以及对听觉刺激的时间响应模式上存在差异。虽然已经表明视觉刺激可以改变听觉皮层的反应幅度，但对于核心区和带区多感官相互作用的差异模式知之甚少。在这里，我们使用功能磁共振成像，研究了在听觉刺激之前呈现的短视觉刺激对听觉皮层中血氧水平依赖信号反应的空间模式的影响。与跨模态抑制一致，光在对应于核心区的皮层区域产生了信号反应的抑制。然而，在对应于带区的周围区域，我们发现了一种反向调制，即信号在离心方向上增加。我们的数据表明，跨模态效应根据听觉皮层的层次化核心 - 带组织进行差异调制。
