Husain F T, Tagamets M-A, Fromm S J, Braun A R, Horwitz B
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA.
Neuroimage. 2004 Apr;21(4):1701-20. doi: 10.1016/j.neuroimage.2003.11.012.
We investigated the neural basis of auditory object processing in the cerebral cortex by combining neural modeling and functional neuroimaging. We developed a large-scale, neurobiologically realistic network model of auditory pattern recognition that relates the neuronal dynamics of cortical auditory processing of frequency modulated (FM) sweeps to functional neuroimaging data of the type obtained using PET and fMRI. Areas included in the model extend from primary auditory to prefrontal cortex. The electrical activities of the neuronal units of the model were constrained to agree with data from the neurophysiological literature regarding the perception of FM sweeps. We also conducted an fMRI experiment using stimuli and tasks similar to those used in our simulations. The integrated synaptic activity of the neuronal units in each region of the model, convolved with a hemodynamic response function, was used as a correlate of the simulated fMRI activity, and generally agreed with the experimentally observed fMRI data in the brain areas corresponding to the regions of the model. Our results demonstrate that the model is capable of exhibiting the salient features of both electrophysiological neuronal activities and fMRI values that are in agreement with empirically observed data. These findings provide support for our hypotheses concerning how auditory objects are processed by primate neocortex.
我们通过结合神经建模和功能神经成像技术，研究了大脑皮层中听觉客体加工的神经基础。我们开发了一个大规模的、具有神经生物学现实意义的听觉模式识别网络模型，该模型将调频（FM）扫描的皮层听觉加工的神经元动力学与使用PET和fMRI获得的功能神经成像数据联系起来。模型中包含的区域从初级听觉皮层延伸到前额叶皮层。模型神经元单元的电活动受到约束，以与神经生理学文献中关于FM扫描感知的数据相一致。我们还进行了一项功能磁共振成像实验，使用了与模拟中相似的刺激和任务。模型每个区域的神经元单元的综合突触活动，与血液动力学响应函数进行卷积，被用作模拟功能磁共振成像活动的相关指标，并且总体上与模型区域对应的脑区中实验观察到的功能磁共振成像数据一致。我们的结果表明，该模型能够展现出与经验观察数据一致的电生理神经元活动和功能磁共振成像值的显著特征。这些发现为我们关于灵长类新皮层如何加工听觉客体的假设提供了支持。
