Sudan Debra
Solid Organ Transplantation Program, University of Nebraska Medical Center, Omaha, Nebraska 68195-3285, USA.
Gastroenterology. 2006 Feb;130(2 Suppl 1):S158-62. doi: 10.1053/j.gastro.2005.09.066.
Intestinal transplantation has become a standard treatment for intestinal failure in patients with life-threatening complications of TPN. Although the long-term survival of patients with continued parenteral nutrition is higher than after intestinal transplantation, the 1 and 2 year survival is comparable. Here we examine other aspects of the treatment options available for patients with intestinal failure including the cost of the therapy and the quality of life. The cost of parenteral nutrition compared to intestinal transplantation reveals that transplantation is cost-effective in patients that maintain graft function within 1 to 3 years after surgery. The quality of life after transplantation is probably equal to or better than quality of life on TPN and children report quality of life similar to normal school children. Although currently reserved for those with life-threatening complications, intestinal transplantation may soon be an option for any patient permanently dependent on parenteral nutrition.
肠道移植已成为患有全胃肠外营养（TPN）危及生命并发症的肠衰竭患者的标准治疗方法。虽然持续接受肠外营养的患者长期生存率高于肠道移植后，但1年和2年生存率相当。在此，我们研究了肠衰竭患者可用治疗方案的其他方面，包括治疗成本和生活质量。肠外营养与肠道移植的成本比较显示，对于术后1至3年内维持移植器官功能的患者，移植具有成本效益。移植后的生活质量可能等于或优于接受TPN时的生活质量，并且儿童报告的生活质量与正常学童相似。虽然目前肠道移植仅用于患有危及生命并发症的患者，但它可能很快会成为任何永久依赖肠外营养患者的一种选择。
