Hampl Monika, Ramp Uwe, Bender Hans G, Kueppers Volkmar
Department of Gynecology and Obstetrics, University Hospital of Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, Germany.
Gynecol Oncol. 2006 Jun;101(3):530-3. doi: 10.1016/j.ygyno.2005.12.035. Epub 2006 Feb 13.
Vulvar carcinoma in young women is rare; so far, no case of an 18-year-old woman has been described. Here, we report a case with a T3 HPV 52-induced tumor 3 years after primary HPV contamination.
An 18-year-old woman without risk factors complaining of dysuria and vulvar pain was treated several months for fungal infection before referred and diagnosed with a vulvar carcinoma located between clitoris and urethra. She underwent operation with partial urethral resection and external radiation. The tumor tested positive for HPV type 52, the time between primary sexual contact and tumor development was less than 3 years.
Also in very young women, an ulcer and vulvar pain have to be biopsied to exclude malignancy despite an unusual short time interval between possible HPV contamination and symptoms.
年轻女性外阴癌罕见；迄今为止，尚未有18岁女性病例的报道。在此，我们报告一例在初次感染人乳头瘤病毒（HPV）3年后由HPV 52诱发的T3期肿瘤病例。
一名无危险因素的18岁女性，主诉排尿困难和外阴疼痛，在转诊并被诊断为位于阴蒂和尿道之间的外阴癌之前，因真菌感染接受了数月治疗。她接受了部分尿道切除术和外照射手术。肿瘤检测出HPV 52呈阳性，初次性接触与肿瘤发生之间的时间间隔不到3年。
即使在非常年轻的女性中，尽管可能的HPV感染与症状之间的时间间隔异常短，但对于溃疡和外阴疼痛也必须进行活检以排除恶性肿瘤。
