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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Sagratella S, Zeng Y C, Frank C, de Carolis A S

Pharmacology Department, Istituto Superiore di Sanita, Roma, Italy.

Gen Pharmacol. 1991;22(2):231-6. doi: 10.1016/0306-3623(91)90438-c.

In in vivo and in vitro studies in rats, the effects of dextromethorphan (DM), dextrorphan (DX), and levorphanol (LV) were compared with those induced by kappa and sigma opiate agonists. 2. In rat hippocampal slices all the morphinans were able to pertubate the CAI hippocampal synaptic transmission, while only DX and LV affected the N-methyl-D-aspartate excitability through a possible interaction at sigma opiate receptors. 3. On the other hand EEG studies show that only DX appears to act as a full agonist at sigma opiate receptors. 4. Present data demonstrate diversified electrophysiological properties of morphinans both in in vitro and in vivo studies.

在对大鼠的体内和体外研究中，将右美沙芬（DM）、右啡烷（DX）和左啡诺（LV）的作用与κ和σ阿片受体激动剂诱导的作用进行了比较。2. 在大鼠海马切片中，所有吗啡喃类药物都能够干扰海马CA1区的突触传递，而只有DX和LV通过与σ阿片受体的可能相互作用影响N-甲基-D-天冬氨酸的兴奋性。3. 另一方面，脑电图研究表明，只有DX似乎在σ阿片受体上作为完全激动剂起作用。4. 目前的数据表明，在体外和体内研究中，吗啡喃类药物具有多样化的电生理特性。

Sagratella S, Zeng Y C, Frank C, de Carolis A S

Pharmacology Department, Istituto Superiore di Sanita, Roma, Italy.

Gen Pharmacol. 1991;22(2):231-6. doi: 10.1016/0306-3623(91)90438-c.

In in vivo and in vitro studies in rats, the effects of dextromethorphan (DM), dextrorphan (DX), and levorphanol (LV) were compared with those induced by kappa and sigma opiate agonists. 2. In rat hippocampal slices all the morphinans were able to pertubate the CAI hippocampal synaptic transmission, while only DX and LV affected the N-methyl-D-aspartate excitability through a possible interaction at sigma opiate receptors. 3. On the other hand EEG studies show that only DX appears to act as a full agonist at sigma opiate receptors. 4. Present data demonstrate diversified electrophysiological properties of morphinans both in in vitro and in vivo studies.

在对大鼠的体内和体外研究中，将右美沙芬（DM）、右啡烷（DX）和左啡诺（LV）的作用与κ和σ阿片受体激动剂诱导的作用进行了比较。2. 在大鼠海马切片中，所有吗啡喃类药物都能够干扰海马CA1区的突触传递，而只有DX和LV通过与σ阿片受体的可能相互作用影响N-甲基-D-天冬氨酸的兴奋性。3. 另一方面，脑电图研究表明，只有DX似乎在σ阿片受体上作为完全激动剂起作用。4. 目前的数据表明，在体外和体内研究中，吗啡喃类药物具有多样化的电生理特性。