伊维菌素注射剂对兔耳螨疥螨的疗效。

Efficacy of an injectable formulation of eprinomectin against Psoroptes cuniculi, the ear mange mite in rabbits.

作者信息

Pan Baoliang, Wang Ming, Xu Farong, Wang Yuwan, Dong Yuntang, Pan Zhende

机构信息

College of Veterinary Medicine, China Agricultural University, 100094 Beijing, China.

出版信息

Vet Parasitol. 2006 Apr 30;137(3-4):386-90. doi: 10.1016/j.vetpar.2006.01.013. Epub 2006 Feb 13.

DOI:10.1016/j.vetpar.2006.01.013

PMID:16473465

Abstract

Thirty rabbits naturally infected with ear mange mite, Psoroptes cuniculi, were subcutaneously administrated with a single dose of eprinomectin at 100, 200 and 300 microg/kg body weight or vehicle on day 0. The extent of lesions was scored on day -6 (prior to treatment), day 0 (treated), days 7, 14, 21, 28 and 35, the ear scabs were collected simultaneously; mites in scabs were examined and counted. The results showed that a single dose of eprinomectin at 200 or 300 microg/kg body weight following subcutaneous administration was able to eliminate P. cuniculi infection in rabbits, and a dose of eprinomectin at 100 microg/kg could significantly reduce mites but was unable to eliminate P. cuniculi.

摘要

30只自然感染兔耳螨（兔痒螨）的兔子于第0天皮下注射单剂量的伊维菌素，剂量分别为100、200和300微克/千克体重，或注射赋形剂。在第-6天（治疗前）、第0天（治疗时）、第7、14、21、28和35天对病变程度进行评分，同时收集耳部结痂；检查并计数痂皮中的螨虫。结果表明，皮下注射200或300微克/千克体重的单剂量伊维菌素能够消除兔痒螨感染，而100微克/千克剂量的伊维菌素可显著减少螨虫数量，但无法消除兔痒螨。