突破屏障：CARD15基因变异如何改变肠壁通透性及群体健康状况
Slipping the barrier: how variants in CARD15 could alter permeability of the intestinal wall and population health.
作者信息
Schreiber S
机构信息
Institute for Clinical Molecular Biology and Department for General Internal Medicine, University-Hospital-Schleswig-Holstein, Schittenhelmstr 12, 24105 Kiel, Germany.
出版信息
Gut. 2006 Mar;55(3):308-9. doi: 10.1136/gut.2005.076075.
Abstract
The increased intestinal permeability in Crohn's disease is associated with the presence of variants in the gene that are regarded as causative for Crohn's disease, suggesting a genetic rather than an environmental background for intestinal barrier dysfunction in Crohn's disease
摘要
克罗恩病中肠道通透性增加与被认为是克罗恩病病因的基因变异的存在有关，这表明克罗恩病中肠道屏障功能障碍的背景是遗传而非环境因素。
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Genetic basis for increased intestinal permeability in families with Crohn's disease: role of CARD15 3020insC mutation?克罗恩病家族中肠道通透性增加的遗传基础：CARD15 3020insC突变的作用？
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Science. 2005 Feb 4;307(5710):734-8. doi: 10.1126/science.1103685.
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Genetic aspects of intestinal permeability in inflammatory bowel disease.
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