药物对刚地弓形虫包囊形式影响的评估。
Evaluation of the effect of drugs on the cyst form of Toxoplasma gondii.
作者信息
Huskinson-Mark J, Araujo F G, Remington J S
机构信息
Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, CA 94301.
出版信息
J Infect Dis. 1991 Jul;164(1):170-1. doi: 10.1093/infdis/164.1.170.
The cyst form of Toxoplasma gondii has been implicated as a cause of recrudescence of the latent infection in congenitally infected patients and in the immunocompromised host. A method was developed to evaluate the effect of drugs on the cyst form of the parasite and used to evaluate a variety of therapeutic agents. The most active compounds against the cyst form in vitro were arprinocid-N-oxide, azithromycin, and the hydroxynaphthoquinone 566C80.
刚地弓形虫的包囊形式被认为是先天性感染患者和免疫功能低下宿主中潜伏感染复发的一个原因。已开发出一种方法来评估药物对该寄生虫包囊形式的作用，并用于评估多种治疗药物。体外对包囊形式最具活性的化合物是阿普林诺西德 - N - 氧化物、阿奇霉素和羟基萘醌566C80。
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