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一系列接受一期姑息手术(采用改良布莱洛克-陶西格分流术或右心室至肺动脉导管)的左心发育不全综合征婴儿的术后早期结果。

Early postoperative outcomes in a series of infants with hypoplastic left heart syndrome undergoing stage I palliation operation with either modified Blalock-Taussig shunt or right ventricle to pulmonary artery conduit.

作者信息

Cua Clifford L, Thiagarajan Ravi R, Gauvreau Kimberlee, Lai Lillian, Costello John M, Wessel David L, Del Nido Pedro J, Mayer John E, Newburger Jane W, Laussen Peter C

机构信息

Department of Cardiology, Children's Hospital, Boston, MA, USA.

出版信息

Pediatr Crit Care Med. 2006 May;7(3):238-44. doi: 10.1097/01.PCC.0000201003.38320.63.

Abstract

OBJECTIVE

Previous publications using nonconcurrent series of patients indicate improved survival for patients with hypoplastic left heart syndrome (HLHS) undergoing stage I palliation with a right ventricle to pulmonary artery conduit (NW-RVPA) vs. a modified Blalock-Taussig shunt (NW-BT). We compared postoperative outcomes in a concurrent series of patients with HLHS undergoing an NW-BT procedure vs. NW-RVPA procedure.

DESIGN

Perioperative data from 66 consecutive patients who underwent NW-BT (n = 37) or NW-RVPA (n = 29) procedures were retrospectively analyzed.

SETTING

Cardiac intensive care unit in a tertiary pediatric hospital.

PATIENTS

Charts were reviewed for all patients with the diagnosis of HLHS undergoing the NW-BT or NW-RVPA procedure between January 2002 and December 2003.

RESULTS

Cardiopulmonary bypass time was longer in the NW-BT group than in the NW-RVPA group (152.5 +/- 52.0 vs. 134.5 +/- 36.1 mins; p = .04). Postoperative diastolic pressures were higher and the Pao2 to Fio2 ratio profiles were lower for the NW-RVPA group over the first 72 hrs. Time to sternal closure (2 [1-6] vs. 4 [2-41] days; p = .01), duration of mechanical ventilation (113 [49-386] vs. 136 [84-764] hrs; p = .01), time to establish enteral feeds (4 [2-8] vs. 5 [3-22] days; p = .01), length of intensive care unit stay (11 [7-55] vs. 15 [8-90] days; p = .04), and length of hospital stay (16 [11-67] vs. 27 [12-126] days; p = .01) were shorter in the NW-RVPA group. Postoperative mortality was not significantly different between the NW-RVPA group (7%) and NW-BT group (11%).

CONCLUSION

At an experienced institution with low stage I palliation mortality for HLHS, there were no differences in early morbidity and mortality between the NW-RVPA and NW-BT procedures. The primary advantage of the NW-RVPA procedure may be faster recovery following surgery and earlier discharge from the hospital.

摘要

目的

以往使用非同期患者系列的出版物表明,与改良布莱洛克 - 陶西格分流术(NW - BT)相比,采用右心室至肺动脉导管(NW - RVPA)进行一期姑息治疗的左心发育不全综合征(HLHS)患者生存率有所提高。我们比较了同期接受NW - BT手术与NW - RVPA手术的HLHS患者的术后结局。

设计

对66例连续接受NW - BT(n = 37)或NW - RVPA(n = 29)手术患者的围手术期数据进行回顾性分析。

地点

一家三级儿科医院的心脏重症监护病房。

患者

回顾了2002年1月至2003年12月期间所有诊断为HLHS并接受NW - BT或NW - RVPA手术患者的病历。

结果

NW - BT组的体外循环时间比NW - RVPA组长(152.5±52.0对134.5±36.1分钟;p = 0.04)。在术后头72小时内,NW - RVPA组的术后舒张压较高,而氧分压与吸入氧浓度比值曲线较低。NW - RVPA组的胸骨闭合时间(2 [1 - 6]对4 [2 - 41]天;p = 0.01)、机械通气时间(113 [49 - 386]对136 [84 - 764]小时;p = 0.01)、建立肠内营养的时间(4 [2 - 8]对5 [3 - 22]天;p = 0.01)、重症监护病房住院时间(11 [7 - 55]对15 [8 - 90]天;p = 0.04)和住院时间(16 [11 - 67]对27 [12 - 126]天;p = 0.01)均较短。NW - RVPA组(7%)和NW - BT组(11%)的术后死亡率无显著差异。

结论

在一家一期姑息治疗HLHS死亡率较低的经验丰富的机构中,NW - RVPA和NW - BT手术在早期发病率和死亡率方面没有差异。NW - RVPA手术的主要优势可能是术后恢复更快且出院更早。

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