Abadi-Korek Ifat, Stark Batya, Zaizov Rina, Shaham Judith
National Institute of Occupational & Environmental Health, Shneider Children's Medical Center of Israel, Petach-Tikva, Israel.
J Occup Environ Med. 2006 Feb;48(2):165-74. doi: 10.1097/01.jom.0000183343.81485.7c.
Parental employment in occupations that have potential exposures to organic solvents or pesticides could be associated with the risk of childhood acute lymphoblastic leukemia (ALL) in their offspring.
We explored this hypothesis by studying the association with respect to exposure time windows. Our case-control study included 224 children, 112 diagnosed with ALL and 112 matched controls.
A significantly higher odds ratio (OR) was found between childhood ALL and reported parental occupational exposures. Analysis of exposures of both parents by exposure time windows revealed significant OR during the preconception and postnatal periods separately.
The results provide support to the association between parental occupational exposures and ALL in their children. These results should be interpreted cautiously because of the small numbers, biases characterizing case-control studies, and the use of hospital-based controls.
父母从事有可能接触有机溶剂或农药的职业，可能与其子女患儿童急性淋巴细胞白血病（ALL）的风险有关。
我们通过研究暴露时间窗的相关性来探讨这一假设。我们的病例对照研究纳入了224名儿童，其中112名被诊断为ALL，112名作为匹配对照。
儿童ALL与报告的父母职业暴露之间发现了显著更高的优势比（OR）。按暴露时间窗对父母双方的暴露情况进行分析，分别在前受孕和产后期间发现了显著的OR。
这些结果支持了父母职业暴露与子女患ALL之间的关联。由于样本量小、病例对照研究存在的偏差以及使用医院对照，这些结果应谨慎解读。
