Ferry N, Edwards M G, Gatehouse J, Capell T, Christou P, Gatehouse A M R
School of Biology, University of Newcastle-upon-Tyne, NE1 7RU, Newcastle-upon-Tyne, UK.
Transgenic Res. 2006 Feb;15(1):13-9. doi: 10.1007/s11248-005-4803-x.
One of the first successes of plant biotechnology has been the creation and commercialisation of transgenic crops exhibiting resistance to major insect pests. First generation products encompassed plants with single insecticidal Bt genes with resistance against major pests of corn and cotton. Modelling studies predicted that usefulness of these resistant plants would be short-lived, as a result of the ability of insects to develop resistance against single insecticidal gene products. However, despite such dire predictions no such collapse has taken place and the acreage of transgenic insect resistance crops has been increasing at a steady rate over the 9 years since the deployment of the first transgenic insect resistant plant. However, in order to assure durability and sustainability of resistance, novel strategies have been contemplated and are being developed. This perspective addresses a number of potentially useful strategies to assure the longevity of second and third generation insect resistant plants.
植物生物技术最早取得的成功之一，是培育出对主要害虫具有抗性的转基因作物并将其商业化。第一代产品包括带有单一杀虫Bt基因、对玉米和棉花的主要害虫具有抗性的植物。建模研究预测，由于昆虫有能力对单一杀虫基因产品产生抗性，这些抗性植物的效用将是短暂的。然而，尽管有如此可怕的预测，但这种崩溃并未发生，自第一种转基因抗虫植物投入使用以来的9年里，转基因抗虫作物的种植面积一直在稳步增加。然而，为了确保抗性的持久性和可持续性，人们已经考虑并正在开发新的策略。这篇综述探讨了一些可能有用的策略，以确保第二代和第三代抗虫植物的长效性。
