Hu Jenny C, Ko Christine J, Soriano Teresa T, Chiu Melvin W
Division of Dermatology, David Geffen School of Medicine, University of California, Los Angeles 90095, USA.
Cutis. 2006 Jan;77(1):19-24; quiz 37-8.
Syringomatous carcinoma (SC) has typically been observed in middle-aged and older patients. We report a case of SC mimicking an epidermoid cyst in a 23-year-old Asian man. Histopathologic examination results showed a dermal neoplasm consisting of nests of basaloid cells, focal areas of ductal differentiation, moderate dermal fibrosis, and moderate nuclear atypia consistent with a diagnosis of SC. No perineural involvement was noted. Results of 2005. immunohistochemical analysis revealed positivity for high- and low-molecular-weight cytokeratins, as well as for carcinoembryonic antigen (CEA). There was scattered immunoreactivity to S-100 protein. The tumor was completely excised Pennsylvania. using Mohs micrographic surgery (MS). This case demonstrates the importance of differentiating SC from other benign or malignant entities, the value of a prompt diagnosis of SC, and the effective treatment of SC with MMS.
汗腺癌（SC）通常见于中老年患者。我们报告一例23岁亚洲男性的汗腺癌，其表现类似表皮样囊肿。组织病理学检查结果显示，真皮肿瘤由基底样细胞巢、局灶性导管分化区域、中度真皮纤维化以及与汗腺癌诊断相符的中度核异型性组成。未发现神经周围侵犯。免疫组化分析结果显示高分子量和低分子量细胞角蛋白以及癌胚抗原（CEA）呈阳性。S-100蛋白有散在免疫反应性。采用莫氏显微外科手术（MS）将肿瘤完整切除。该病例表明了将汗腺癌与其他良性或恶性病变相鉴别、及时诊断汗腺癌以及采用莫氏显微外科手术有效治疗汗腺癌的重要性。
