Otte S, Bressel M, Thiedemann C, Arps H, Kastendieck H
Urologische Abteilung, Allgemeines Krankenhaus Hamburg-Harburg.
Urologe A. 1991 Mar;30(2):89-91.
Between 26/2/88 and 23/6/88 we treated four patients with signet ring cell carcinoma of the urinary tract. There was no conformity in clinical development, results of laboratory investigations, histomorphology or symptoms. For the first time, DNA cytophotometry was used to examine histological preparations of urinary signet ring cell carcinoma. This method provides information about the prognosis of the malignant disease, as it reveals the DNA distribution in the tumor cells. In three cases there was a clearly pathologic so-called an-euploid DNA distribution, indicating the high malignant potency of this tumor entity.
1988年2月26日至1988年6月23日期间，我们对4例泌尿道印戒细胞癌患者进行了治疗。这些患者在临床进展、实验室检查结果、组织形态学或症状方面均无一致性表现。我们首次运用DNA细胞光度测定法对泌尿道印戒细胞癌的组织学标本进行检查。该方法能够揭示肿瘤细胞中的DNA分布情况，从而为这种恶性疾病的预后提供信息。在3例患者中，出现了明显病理性的所谓非整倍体DNA分布，这表明该肿瘤实体具有很高的恶性潜能。
