PTCH基因表达作为食管鳞状细胞癌的一种潜在标志物。
PTCH gene expression as a potential marker for esophageal squamous cell carcinoma.
作者信息
Ishiyama Akiharu, Hibi Kenji, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro, Ito Katsuki, Nakao Akimasa
机构信息
Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan.
出版信息
Anticancer Res. 2006 Jan-Feb;26(1A):195-8.
BACKGROUND
The PTCH expression level in esophageal squamous cell carcinoma (SCC) was examined.
MATERIALS AND METHODS
To test whether PTCH can serve as a candidate marker for esophageal SCC, a quantitative reverse transcription (RT) -PCR for the PTCH gene was performed and the possible relationship between PTCH gene expression levels and clinicopathological findings in esophageal SCC was evaluated.
RESULTS
A low PTCH expression score was observed in 18 out of 29 (62%) esophageal SCCs and it was significantly correlated with a poor prognosis in esophageal SCC patients (p = 0.0073).
CONCLUSION
These results suggest that PTCH might serve as a new parameter for the prediction of prognosis in esophageal SCC.
背景
检测食管鳞状细胞癌（SCC）中PTCH的表达水平。
材料与方法
为检测PTCH是否可作为食管SCC的候选标志物，进行了PTCH基因的定量逆转录（RT）-PCR，并评估了PTCH基因表达水平与食管SCC临床病理结果之间的可能关系。
结果
29例食管SCC中有18例（62%）观察到PTCH低表达评分，且其与食管SCC患者的不良预后显著相关（p = 0.0073）。
结论
这些结果表明，PTCH可能作为预测食管SCC预后的新参数。
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