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[卡巴胆碱诱导的长期解离状态发生过程中突触膜蛋白的磷酸化作用]

[The phosphorylation of synaptic membrane proteins in the occurrence of prolonged dissociative states induced by carbacholine].

作者信息

Arkhipov V I, Shchipakina T G

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1991 Jan-Feb;41(1):162-7.

PMID:1647583
Abstract

Prolonged dissociated state of rats resulting from carbaholine stimulation of m-cholinoreceptors was studied by determining phosphorylation of synaptic membranes proteins. Unusually strong and prolonged activation was found in the process of phosphorylation of the hippocampus synaptic proteins under the influence of single carbaholine administration. Conclusion is made about direct participation of the hippocampus in mechanisms of memory dissociation and also about perspectiveness of the applied method for functional characteristics of separate brain structures.

摘要

通过测定突触膜蛋白的磷酸化,研究了卡巴胆碱刺激M胆碱受体导致大鼠的长时间分离状态。单次给予卡巴胆碱后,在海马突触蛋白磷酸化过程中发现了异常强烈且持久的激活。得出海马直接参与记忆分离机制的结论,以及所应用方法对单独脑结构功能特性研究的前景。

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