Joyce Peter R, McKenzie Janice M, Mulder Roger T, Luty Suzanne E, Sullivan Patrick F, Miller Allison L, Kennedy Martin A
Department of Psychological Medicine, Christchurch School of Medicine and Health Sciences, New Zealand.
Aust N Z J Psychiatry. 2006 Mar;40(3):225-9. doi: 10.1080/j.1440-1614.2006.01778.x.
To examine whether the T allele of G protein beta3 (GNbeta3) is associated with self-mutilation in depressed patients.
A history of self-mutilation was systematically inquired about when recruiting depressed patients for a long-term treatment trial. Risk factors such as borderline personality disorder and childhood abuse experiences were systematically assessed, and patients were genotyped for polymorphisms of GNbeta3.
The T allele of GNbeta3, borderline personality disorder and childhood sexual abuse were all significantly associated with self-mutilation in depressed patients. These associations were significant in both univariate and multivariate analyses, and as predicted were stronger in young depressed patients than in depressed patients of all ages.
If the association between the T allele of GNbeta3 and self-mutilation can be replicated, this may provide clues to understanding the neurobiology of self-mutilation.
研究G蛋白β3亚基（GNβ3）的T等位基因是否与抑郁症患者的自残行为有关。
在招募抑郁症患者进行长期治疗试验时，系统询问自残史。系统评估边缘性人格障碍和童年期受虐经历等危险因素，并对患者进行GNβ3多态性基因分型。
GNβ3的T等位基因、边缘性人格障碍和童年期性虐待均与抑郁症患者的自残行为显著相关。这些关联在单变量和多变量分析中均显著，且如预期的那样，在年轻抑郁症患者中比在所有年龄段的抑郁症患者中更强。
如果GNβ3的T等位基因与自残行为之间的关联能够被重复验证，这可能为理解自残行为的神经生物学机制提供线索。
