Hill Stuart P, Montes de Oca Horacio, Klein Phil G, Ward Ian M, Rose John, Farrar David
IRC in Polymer Science and Technology, School of Physics and Astronomy, University of Leeds, Leeds, LS2 9JT, UK.
Biomaterials. 2006 Jun;27(17):3168-77. doi: 10.1016/j.biomaterials.2006.01.025. Epub 2006 Feb 14.
Hydrolytic degradation studies have been undertaken on Maxon B, a bioresorbable block copolymer of polyglycolic acid (PGA) and polytrimethylene carbonate (TMC). Isotropic and oriented samples were studied by dynamic mechanical measurements over a wide range of temperatures. In addition to mechanical tests, water content and mass loss were also determined on the degraded samples. At early stages of degradation water content was the dominant factor and plasticisation lead to reductions in the glass transition temperatures of the PGA and TMC components. Orientation was shown to give significant improvements in the mechanical properties, including overall increases in modulus and an increase in the glass transition temperature of the PGA component, which is important for the behaviour at body temperature (37 degrees C). Oriented samples also showed significantly less reduction in mechanical properties on degradation. Simple one-dimensional Takayanagi models were used to provide useful insight into the understanding of the mechanical behaviour.
已对马克森B（Maxon B）进行了水解降解研究，马克森B是聚乙醇酸（PGA）和聚三亚甲基碳酸酯（TMC）的一种生物可吸收嵌段共聚物。通过在很宽的温度范围内进行动态力学测量，对各向同性和取向样品进行了研究。除了力学测试外，还测定了降解样品的含水量和质量损失。在降解的早期阶段，含水量是主要因素，增塑导致PGA和TMC组分的玻璃化转变温度降低。结果表明，取向显著改善了力学性能，包括模量的整体增加以及PGA组分玻璃化转变温度的升高，这对于在体温（37摄氏度）下的性能很重要。取向样品在降解时力学性能的降低也明显较少。使用简单的一维高柳模型（Takayanagi models）有助于深入理解力学行为。
