Gawaz Meinrad
Medizinische Klinik III, Eberhard Karls Universität Tübingen, Otfried-Müller-Strasse 10, D-72076 Tübingen, Germany.
Blood Cells Mol Dis. 2006 Mar-Apr;36(2):206-10. doi: 10.1016/j.bcmd.2005.12.022. Epub 2006 Feb 13.
Beyond their role in hemostasis and thrombosis platelets are critically involved in the onset of atherosclerosis. Platelets represent an important linkage between inflammation, and atherogenesis. Platelets interact with inflammatory cells including leukocytes and endothelium. These interactions lead to leukocyte recruitment towards the vascular wall, initiating extravasation of circulating mononuclear cells and foam cell generation. Inflammatory processes within the arterial wall result in development of atherosclerotic lesions and atheroprogression. Inhibition of platelet interaction with the arterial wall results in attenuation of atherosclerosis and may be a novel therapeutic strategy in treatment of high-risk patients.
除了在止血和血栓形成中的作用外，血小板在动脉粥样硬化的发生中也起着关键作用。血小板是炎症和动脉粥样硬化形成之间的重要联系。血小板与包括白细胞和内皮细胞在内的炎症细胞相互作用。这些相互作用导致白细胞向血管壁募集，引发循环单核细胞的外渗和泡沫细胞的生成。动脉壁内的炎症过程导致动脉粥样硬化病变的发展和动脉粥样硬化进展。抑制血小板与动脉壁的相互作用可导致动脉粥样硬化的减轻，这可能是治疗高危患者的一种新的治疗策略。
