Aisenbrey Sabine, Lafaut Bart A, Szurman Peter, Hilgers Ralph-Dieter, Esser Peter, Walter Peter, Bartz-Schmidt Karl U, Thumann Gabriele
Center of Ophthalmology, Department of Vitreoretinal Surgery, Eberhard-Karls University Tuebingen, Tuebingen, Germany.
Arch Ophthalmol. 2006 Feb;124(2):183-8. doi: 10.1001/archopht.124.2.183.
To report the functional and anatomical outcome of 20 patients who underwent surgical removal of choroidal neovascularization combined with transplantation of autologous iris pigment epithelial cells to the subretinal space 3 years after treatment.
Freshly isolated autologous iris pigment epithelial cells were translocated to the subretinal space in 20 patients after membrane extraction. Patients were followed up by funduscopy, angiography, microperimetry, and visual acuity testing.
After a follow-up of 3 years, 1 patient showed improved visual acuity, 13 patients retained stable visual acuity, and 3 patients had reduced visual acuity. No macular edema or recurrent choroidal neovascularization was apparent at any time during the follow-up.
Transplanted autologous iris pigment epithelial cells were well tolerated for 3 years and stabilization of visual acuity was achieved in most patients. These results suggest that iris pigment epithelial cells may serve as a substitute for retinal pigment epithelial cells after choroidal neovascularization removal in patients with exudative macular degeneration; however, whether these cells will be of any value for the restoration of vision and possible protection against choroidal neovascularization recurrence awaits further clinical observation and additional research.
报告20例接受脉络膜新生血管手术切除并于治疗3年后将自体虹膜色素上皮细胞移植至视网膜下间隙患者的功能及解剖学转归。
20例患者在膜切除术后将新鲜分离的自体虹膜色素上皮细胞移植至视网膜下间隙。通过眼底镜检查、血管造影、微视野检查及视力测试对患者进行随访。
随访3年后，1例患者视力提高，13例患者视力保持稳定，3例患者视力下降。随访期间任何时候均未出现黄斑水肿或脉络膜新生血管复发。
移植的自体虹膜色素上皮细胞3年内耐受性良好，大多数患者视力得以稳定。这些结果表明，对于渗出性黄斑变性患者，在脉络膜新生血管切除后，虹膜色素上皮细胞可替代视网膜色素上皮细胞；然而，这些细胞对视力恢复是否有价值以及能否预防脉络膜新生血管复发，仍有待进一步的临床观察和更多研究。
