口服避孕药与头痛患病率增加：挪威特隆赫姆市健康研究（Head-HUNT研究）

Oral contraceptives and increased headache prevalence: the Head-HUNT Study.

作者信息

Aegidius K, Zwart J-A, Hagen K, Schei B, Stovner L J

机构信息

Department of Neuroscience, Norwegian National Headache Centre, St. Olav's University Hospital, Trondheim, Norway.

出版信息

Neurology. 2006 Feb 14;66(3):349-53. doi: 10.1212/01.wnl.0000196481.57994.09.

DOI:10.1212/01.wnl.0000196481.57994.09

PMID:16476933

Abstract

OBJECTIVE

To examine the prevalence of headache and migraine among women using oral contraceptives (OCs) in a large, cross-sectional population-based study.

METHODS

In the Nord-Trøndelag Health Study in Norway 1995-1997 (HUNT 2), 27,700 (60%) out of 46,506 invited women responded to headache questions (Head-HUNT). Among 14,353 premenopausal women, 13,944 (97%) responded to questions regarding use of contraceptives.

RESULTS

There was a significant association between headache and reported use of estrogen-containing OCs in premenopausal women, both for migraine (OR = 1.4, 95% CI = 1.2 to 1.7) and for non-migrainous headache (OR = 1.2, 95% CI = 1.0 to 1.4). A significant dose relationship between headache and the amount of estrogen in the OCs could not be demonstrated. No significant association between headache and OCs containing only gestagen was found.

CONCLUSION

Headache, especially migraine, was more likely among premenopausal women using oral contraceptives containing estrogen.

摘要

目的

在一项基于人群的大型横断面研究中，调查使用口服避孕药（OCs）的女性中头痛和偏头痛的患病率。

方法

在1995 - 1997年挪威北特伦德拉格郡健康研究（HUNT 2）中，46,506名受邀女性中有27,700名（60%）回答了头痛相关问题（Head - HUNT）。在14,353名绝经前女性中，13,944名（97%）回答了关于避孕药使用的问题。

结果

绝经前女性中，头痛与报告使用含雌激素的口服避孕药之间存在显著关联，偏头痛（比值比[OR]=1.4，95%置信区间[CI]=1.2至1.7）和非偏头痛性头痛（OR = 1.2，95% CI = 1.0至1.4）均如此。未证实头痛与口服避孕药中雌激素含量之间存在显著剂量关系。未发现头痛与仅含孕激素的口服避孕药之间存在显著关联。