Aamodt A H, Borch-Iohnsen B, Hagen K, Stovner L J, Asberg A, Zwart J-A
Norwegian National Headache Centre, Trondheim University Hospital, Trondheim, Norway.
Cephalalgia. 2004 Sep;24(9):758-62. doi: 10.1111/j.1468-2982.2004.00756.x.
As clinic-based studies show an association between headache and both high and low levels of haemoglobin, we analysed this relationship in a population-based cross-sectional study (the HUNT Study). A total of 2385 women aged 20-55 years responded to a headache questionnaire and gave blood samples for measuring haemoglobin and ferritin. In the multivariate analyses, adjusting for age and education, there was a linear trend of decreasing prevalence of headache (P = 0.02) and migraine (P = 0.01) with decreasing haemoglobin. In particular, migraine was less likely among women with low haemoglobin (values < 11.5 g/dl) (odds ratio 0.4, confidence interval 0.2, 0.9). There was no correlation between headache prevalence and ferritin. The present findings may be relevant for the headache reported in polycythaemia and chronic altitude sickness.
由于基于诊所的研究表明头痛与血红蛋白水平过高和过低均有关联，我们在一项基于人群的横断面研究（HUNT研究）中分析了这种关系。共有2385名年龄在20至55岁之间的女性回答了头痛问卷，并提供了血液样本以测量血红蛋白和铁蛋白。在多变量分析中，对年龄和教育程度进行调整后，随着血红蛋白水平降低，头痛（P = 0.02）和偏头痛（P = 0.01）的患病率呈线性下降趋势。特别是，血红蛋白水平低（值<11.5 g/dl）的女性患偏头痛的可能性较小（比值比0.4，置信区间0.2，0.9）。头痛患病率与铁蛋白之间无相关性。目前的研究结果可能与真性红细胞增多症和慢性高原病中报告的头痛有关。
