Heikkonen E, Mäki T, Kontula K, Ylikahri R, Härkönen M
Research Unit of Alcohol Diseases, University Central Hospital, Helsinki, Finland.
Alcohol Clin Exp Res. 1991 Mar;15(2):291-4. doi: 10.1111/j.1530-0277.1991.tb01871.x.
The combined effects of alcohol intoxication and intense physical exercise on the adrenergic system were studied in eight healthy male volunteers. Ethanol (0.8 g/kg body weight) was administered perorally to bring about a mean serum concentration of 21 mmol/liter (0.1%); each subject also participated in an identical control session without alcohol. Acute alcohol intake alone did not change the concentrations of plasma adrenaline or noradrenaline or the density, affinity, and functioning (ability to mediate catecholamine-stimulated production of cAMP) of lymphocytic beta-adrenergic receptors. In contrast, acute ergometer exercise brought about an approximately 10-fold increase of plasma adrenaline and noradrenaline concentrations, a 2- to 3-fold increase of beta-adrenergic receptor density and an enhancement of isoproterenol-stimulated cAMP production. Alcohol intake immediately before the ergometer exercise did not modify these changes. In conclusion, acute physical exercise activates the human adrenergic system, with an increase of both plasma catecholamines and lymphocytic beta-adrenergic receptors. Moderate alcohol intoxication does not affect exercise-induced alterations of these parameters.
在八名健康男性志愿者中研究了酒精中毒和剧烈体育锻炼对肾上腺素能系统的联合作用。口服乙醇（0.8克/千克体重）以使血清平均浓度达到21毫摩尔/升（0.1%）；每名受试者还参加了一次无酒精的相同对照试验。单独急性摄入酒精不会改变血浆肾上腺素或去甲肾上腺素的浓度，也不会改变淋巴细胞β-肾上腺素能受体的密度、亲和力和功能（介导儿茶酚胺刺激产生环磷酸腺苷的能力）。相比之下，急性测力计运动使血浆肾上腺素和去甲肾上腺素浓度增加约10倍，β-肾上腺素能受体密度增加2至3倍，并增强异丙肾上腺素刺激的环磷酸腺苷产生。在测力计运动前立即摄入酒精并未改变这些变化。总之，急性体育锻炼会激活人体肾上腺素能系统，使血浆儿茶酚胺和淋巴细胞β-肾上腺素能受体均增加。中度酒精中毒不会影响运动引起的这些参数变化。
