Schaller K, Mechau D, Scharmann H G, Weiss M, Baum M, Liesen H
Institute of Sports Medicine, University of Paderborn, 33098 Paderborn, Germany.
J Appl Physiol (1985). 1999 Jul;87(1):317-24. doi: 10.1152/jappl.1999.87.1.317.
The influence of increased training on the sympathoadrenergic system was investigated. Moderately trained male subjects (n = 15) increased their training within 10 wk by 60%; eight of the subjects increased their training volume, and seven increased their training intensity. Before and after the training, an exhaustive treadmill exercise was carried out. Acute treadmill exercise increased beta-adrenergic receptor number on mononuclear lymphocytes, isoproternol-stimulated cAMP production, and plasma catecholamine concentration. The increase of receptor number can at least partially be explained by a changed lymphocyte composition at rest and after exercise. After training, the exercise-induced increase of beta-adrenergic receptor number was significantly blunted, and the exercise-induced increase of the isoproternol-stimulated cAMP production per beta-receptor was enhanced. Subjects who experienced increased symptoms of physical discomfort and/or mood changes showed an enhanced cAMP production after training. These findings point to an altered regulation of the receptor and postreceptor mechanisms as an effect of a 10-wk period of hard training.
研究了增加训练对交感肾上腺素能系统的影响。中度训练的男性受试者（n = 15）在10周内将训练量增加了60%；其中8名受试者增加了训练量，7名受试者增加了训练强度。在训练前后，进行了一次力竭性跑步机运动。急性跑步机运动增加了单核淋巴细胞上β-肾上腺素能受体数量、异丙肾上腺素刺激的环磷酸腺苷（cAMP）生成以及血浆儿茶酚胺浓度。受体数量的增加至少部分可以通过静息和运动后淋巴细胞组成的变化来解释。训练后，运动诱导的β-肾上腺素能受体数量增加明显减弱，且每个β受体的异丙肾上腺素刺激的cAMP生成的运动诱导增加增强。经历身体不适和/或情绪变化症状增加的受试者在训练后cAMP生成增强。这些发现表明，作为10周高强度训练的结果，受体和受体后机制的调节发生了改变。
