Ehehalt Robert, Füllekrug Joachim, Pohl Jürgen, Ring Axel, Herrmann Thomas, Stremmel Wolfgang
Department of Internal Medicine IV, Gastroenterology, University of Heidelberg, Heidelberg, Germany.
Mol Cell Biochem. 2006 Mar;284(1-2):135-40. doi: 10.1007/s11010-005-9034-1. Epub 2006 Feb 14.
Translocation of long chain fatty acids across the plasma membrane is achieved by a concert of co-existing mechanisms. These lipids can passively diffuse, but transport can also be accelerated by certain membrane proteins as well as lipid rafts. Lipid rafts are dynamic assemblies of proteins and lipids, that float freely within the two dimensional matrix of the membrane bilayer. They are receiving increasing attention as devices that regulate membrane function in vivo and play an important role in membrane trafficking and signal transduction. In this review we will discuss how lipid rafts might be involved in the uptake process and how the candidate proteins for fatty acid uptake FAT/CD36 and the FATP proteins interact with these domains. We will also discuss the functional role of FATPs in general. To our understanding FATPs are indirectly involved in the translocation process across the plasma membrane by providing long chain fatty acid synthetase activity.
长链脂肪酸穿过质膜是通过多种共存机制协同完成的。这些脂质可以被动扩散，但某些膜蛋白以及脂筏也能加速其转运。脂筏是蛋白质和脂质的动态聚集体，在膜双层的二维基质中自由漂浮。作为在体内调节膜功能的装置，它们受到越来越多的关注，并在膜运输和信号转导中发挥重要作用。在本综述中，我们将讨论脂筏可能如何参与摄取过程，以及脂肪酸摄取候选蛋白FAT/CD36和FATP蛋白如何与这些结构域相互作用。我们还将讨论FATP蛋白的一般功能作用。据我们了解，FATP通过提供长链脂肪酸合成酶活性间接参与跨质膜的转运过程。
