Ito Takashi, Sakakibara Ryuji, Yamamoto Tatsuya, Uchiyama Tomoyuki, Liu Zhi, Asahina Masato, Higashi Morihiro, Arai Kimihito, Ito Shoichi, Awa Yusuke, Yamamoto Kaori, Kinou Mika, Yamanishi Tomonori, Hattori Takamichi
Neurology Dept., Chiba University, 1-8-1 Inohana Chuo-ku, Chiba 260-8670, Japan.
Clin Auton Res. 2006 Feb;16(1):66-71. doi: 10.1007/s10286-006-0319-6.
Uro-neurological assessment was performed in four patients with small-fiber neuropathy due to amyloidosis (2 transthyretin-type/2 immunoglobulin light-chain-type). Voiding difficulties were due to detrusor weakness and impaired bladder sensation. In two patients cholinesterase inhibition treatment caused urge incontinence, indicating detrusor denervation supersensitivity. The underlying mechanisms of urinary dysfunction seem to involve postganglionic cholinergic and afferent somatic nerves.
对4例因淀粉样变性（2例转甲状腺素蛋白型/2例免疫球蛋白轻链型）导致小纤维神经病变的患者进行了泌尿神经学评估。排尿困难是由于逼尿肌无力和膀胱感觉受损所致。在2例患者中，胆碱酯酶抑制治疗导致急迫性尿失禁，提示逼尿肌去神经超敏反应。泌尿功能障碍的潜在机制似乎涉及节后胆碱能神经和传入躯体神经。
