Fernández-Rodríguez Manuel A, Shen Qilong, Hartwig John F
Department of Chemistry, Yale University, PO Box 208107 New Haven, CT 06520-8107, USA.
J Am Chem Soc. 2006 Feb 22;128(7):2180-1. doi: 10.1021/ja0580340.
A general catalytic system for the coupling of aryl halides and sulfonates with thiols based on the use of the CyPF-t-Bu ligand (1) is reported. The reactions catalyzed by complexes of 1 occur in excellent yields with broad scope and exhibit extraordinary turnover numbers and high tolerance of functional groups. Turnover numbers usually exceed those of previous catalysts by 2 or 3 orders of magnitude. In addition, the reactions of aryl tosylates with alkane thiols to form aryl sulfides are reported for the first time. Finally, the synthesis of a diarylsulfide from two bromoarenes was accomplished using a hydrogen sulfide surrogate.
报道了一种基于使用CyPF-t-Bu配体（1）的用于芳基卤化物和磺酸盐与硫醇偶联的通用催化体系。由1的配合物催化的反应产率优异、范围广泛，具有极高的周转数和对官能团的高耐受性。周转数通常比以前的催化剂高出2或3个数量级。此外，首次报道了芳基甲苯磺酸盐与链烷硫醇反应形成芳基硫醚。最后，使用硫化氢替代物由两种溴代芳烃合成了二芳基硫醚。
