Fernández-Rodríguez Manuel A, Shen Qilong, Hartwig John F
Department of Chemistry, Yale University P.O. Box 208107, New Haven, CT 06520-8107, USA.
Chemistry. 2006 Oct 16;12(30):7782-96. doi: 10.1002/chem.200600949.
The cross-coupling reaction of aryl chlorides with aliphatic and aromatic thiols catalyzed by palladium complexes of the strongly binding bisphosphine CyPF-tBu ligand (1) is reported. Most of the reactions catalyzed by complexes of ligand 1 occur with turnover numbers that exceed those of previous catalysts by two orders of magnitude. The reactions occur with excellent yields, broad scope and high tolerance of functional groups. Coupling of aryl halides with thiols in the presence of low loadings of catalysts derived from other Josiphos type ligands, as well as ligands of other structural types, are also described.
报道了由强配位双膦CyPF-tBu配体(1)的钯配合物催化的芳基氯化物与脂肪族和芳香族硫醇的交叉偶联反应。配体1的配合物催化的大多数反应的周转数比以前的催化剂高出两个数量级。这些反应产率优异、适用范围广且对官能团具有高耐受性。还描述了在低负载量的源自其他Josiphos型配体以及其他结构类型配体的催化剂存在下芳基卤化物与硫醇的偶联反应。
