Myers Robert R, Campana W Marie, Shubayev Veronica I
Department of Anesthesiology (0629), University of California-San Diego, La Jolla, CA 92093-0629, USA.
Drug Discov Today. 2006 Jan;11(1-2):8-20. doi: 10.1016/S1359-6446(05)03637-8.
Neuroinflammation is a proinflammatory cytokine-mediated process that can be provoked by systemic tissue injury but it is most often associated with direct injury to the nervous system. It involves neural-immune interactions that activate immune cells, glial cells and neurons and can lead to the debilitating pain state known as neuropathic pain. It occurs most commonly with injury to peripheral nerves and involves axonal injury with Wallerian degeneration mediated by hematogenous macrophages. Therapy is problematic but new trials with anti-cytokine agents, cytokine receptor antibodies, cytokine-signaling inhibitors, and glial and neuron stabilizers provide hope for future success in treating neuropathic pain.
神经炎症是一种由促炎细胞因子介导的过程，可由全身性组织损伤引发，但最常与神经系统的直接损伤相关。它涉及神经-免疫相互作用，激活免疫细胞、神经胶质细胞和神经元，并可导致被称为神经性疼痛的衰弱性疼痛状态。它最常见于周围神经损伤，涉及轴突损伤以及由血源性巨噬细胞介导的华勒氏变性。治疗存在问题，但使用抗细胞因子药物、细胞因子受体抗体、细胞因子信号抑制剂以及神经胶质细胞和神经元稳定剂的新试验为未来成功治疗神经性疼痛带来了希望。
