Mutoh Michihiro, Akasu Takayuki, Takahashi Mami, Niho Naoko, Yoshida Teruhiko, Sugimura Takashi, Wakabayashi Keiji
Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan.
Jpn J Clin Oncol. 2006 Mar;36(3):166-71. doi: 10.1093/jjco/hyi233. Epub 2006 Feb 14.
Familial adenomatous polyposis (FAP) results from germline adenomatous polyposis coli (APC) gene mutations and many affected patients die from colorectal cancers which arise from colorectal polyps. We previously reported that two strains of Apc gene-deficient mice developing multiple intestinal polyps exhibit a hyperlipidemic state. The triglyceride (TG) levels were approximately 10-fold higher than the levels observed in wild-type mice.
To examine whether a positive relationship might exist between hyperlipidemia and colorectal tumor development in FAP patients, as with Apc gene-deficient mice, a pilot experiment was performed using readily available clinical data such as ages, serum lipid levels, number of colorectal polyps and cancer development in 28 FAP patients from the National Cancer Center Hospital, Japan.
The overall prevalence of hyperlipidemia in FAP cases was 58%. Average TG levels in the 40-60 year age groups of FAP patients were > or =150 mg/dl (the defined threshold level of hyperlipidemia). Moreover, there was a tendency for higher serum TG levels in patients who developed colorectal cancer, as compared with those without colorectal cancer.
These results show that a hyperlipidemic state occurs in FAP patients. Although it is weaker than that in Apc gene-deficient mice, it may be linked to colon tumor development. These data warrant further studies for wider populations of FAP patients.
家族性腺瘤性息肉病（FAP）由种系腺瘤性息肉病基因（APC）突变引起，许多患病患者死于由结肠息肉发展而来的结直肠癌。我们之前报道过，两株发生多个肠道息肉的Apc基因缺陷小鼠呈现出高脂血症状态。甘油三酯（TG）水平比野生型小鼠中观察到的水平高出约10倍。
为了研究在FAP患者中高脂血症与结直肠肿瘤发生之间是否可能存在正相关关系，如同Apc基因缺陷小鼠那样，利用日本国立癌症中心医院28例FAP患者的现成临床数据，如年龄、血脂水平、结肠息肉数量和癌症发生情况，进行了一项初步实验。
FAP病例中高脂血症的总体患病率为58%。FAP患者40 - 60岁年龄组的平均TG水平≥150 mg/dl（高脂血症的定义阈值水平）。此外，与未发生结直肠癌的患者相比，发生结直肠癌的患者血清TG水平有升高趋势。
这些结果表明FAP患者会出现高脂血症状态。尽管其程度比Apc基因缺陷小鼠中的要轻，但可能与结肠肿瘤发生有关。这些数据值得对更广泛的FAP患者群体进行进一步研究。
