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血清脂质与大肠息肉形成之间的关系

The Relationship Between Serum Lipids and the Formation of Colorectal Polyps.

作者信息

Düzköylü Yiğit, Demircioğlu Mahmut Kaan, Kılavuz Hüseyin, Sari Serkan

机构信息

Gastroenterological Surgery, Başakşehir Çam and Sakura City Hospital, İstanbul, TUR.

Surgical Oncology, Umraniye Training and Research Hospital, İstanbul, TUR.

出版信息

Cureus. 2024 Apr 3;16(4):e57511. doi: 10.7759/cureus.57511. eCollection 2024 Apr.

DOI:10.7759/cureus.57511
PMID:38706995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11066730/
Abstract

BACKGROUND AND AIMS

Obesity, metabolic syndrome, and hyperlipidemia are known as risk factors for colorectal tumors. Colorectal polyps are accepted as potential precursors of colorectal cancer (CRC). This study was designed to clarify the association between the levels of serum lipids and the presence of colorectal polyps.

METHODS

This study was conducted at Basaksehir Cam and Sakura City Hospital, Gastroenterological Surgery Clinic, Istanbul, Turkey. We retrospectively analyzed patients who underwent colonoscopy with serum lipid profile within one month for a one-year period. Groups were analyzed in terms of the correlation between hyperlipidemia and the formation of polyps. The study group was also evaluated in terms of the polyp type, localization, and number.

RESULTS

Among 453 patients, females were 248 and males were 211, with a mean age of 56.7. The study and control groups involved 259 and 194 patients, respectively. The age and serum levels of low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglyceride (TG) were found to be statistically significant in terms of polyp presence and number (p < 0.05).

CONCLUSION

Colorectal polyps are well-known precursors of CRC. We found that the combination of elevated serum levels of low-density lipoprotein cholesterol, total cholesterol, and triglycerides may be a risk predictor for the presence of colorectal polyps, which can be advantageous in cancer screening.

摘要

背景与目的

肥胖、代谢综合征和高脂血症被认为是结直肠肿瘤的危险因素。结直肠息肉被公认为是结直肠癌（CRC）的潜在前体。本研究旨在阐明血脂水平与结直肠息肉存在之间的关联。

方法

本研究在土耳其伊斯坦布尔巴塞希尔卡姆和樱花市医院胃肠外科诊所进行。我们回顾性分析了在一年时间内，在一个月内接受结肠镜检查并伴有血脂谱的患者。根据高脂血症与息肉形成之间的相关性对各组进行分析。还根据息肉类型、位置和数量对研究组进行了评估。

结果

453例患者中，女性248例，男性211例，平均年龄56.7岁。研究组和对照组分别有259例和194例患者。就息肉的存在和数量而言，低密度脂蛋白胆固醇（LDL-C）、总胆固醇（TC）和甘油三酯（TG）的年龄和血清水平在统计学上具有显著意义（p < 0.05）。

结论

结直肠息肉是众所周知的结直肠癌前体。我们发现，血清低密度脂蛋白胆固醇、总胆固醇和甘油三酯水平升高的组合可能是结直肠息肉存在的风险预测指标，这在癌症筛查中可能具有优势。