Ost Michael C, Lee Benjamin R
Department of Urology, North Shore-Long Island Jewish Medical Center New Hyde Park, New York 11040, USA.
Curr Opin Urol. 2006 Mar;16(2):93-9. doi: 10.1097/01.mou.0000193376.07071.ac.
Despite major advances in the urological care of spinal cord injury patients, the incidence of urolithiasis has not changed. Although the incidence of kidneys lost to staghorn calculus disease has decreased considerably, stone disease is still a significant cause of morbidity and concern. The purpose of this review is to summarize the risk factors for the development of stone diseases in the spinal cord injury patient population and present the outcomes of current endourologic treatment modalities.
Recurrent urinary tract infections, indwelling catheters, vesicoureteral reflux, and immobilization hypercalcuria are a few of the major risk factors for the development of urolithiasis among spinal cord injury patients. Retrograde endourologic techniques are often not possible to address stone disease due to lower extremity contractures, spinal curvature, and pelvic tilt. Extracorporeal shockwave lithotripsy success rates vary from 50 to 90%, but clearance rates are often delayed. Success rates for percutaneous nephrolithotomy match those quoted in the general population ( > 90%), but at the expense of a higher rate of complications (6-20%). Meticulous planning with regard to appropriate prophylactic antibiotics and body position will maximize efficacious outcomes.
Early identification and treatment of urolithiasis in spinal cord injury patients will aid in preserving renal function and minimizing associated complications. Despite variation in common urological practices between spinal cord injury units and the lack of clear cut guidelines for follow-up, the increased incidence of risks associated with urolithiasis lends support for routine genitourinary imaging in order to identify and treat those individuals at highest risk.
尽管脊髓损伤患者的泌尿外科护理取得了重大进展,但尿路结石的发病率并未改变。虽然鹿角形结石病导致肾脏丧失的发生率已大幅下降,但结石病仍是发病和令人担忧的重要原因。本综述的目的是总结脊髓损伤患者群体中结石病发生的危险因素,并介绍当前腔内泌尿外科治疗方式的效果。
复发性尿路感染、留置导尿管、膀胱输尿管反流和制动性高钙尿症是脊髓损伤患者发生尿路结石的一些主要危险因素。由于下肢挛缩、脊柱侧弯和骨盆倾斜,逆行腔内泌尿外科技术往往无法用于治疗结石病。体外冲击波碎石术的成功率在50%至90%之间,但结石清除率往往延迟。经皮肾镜取石术的成功率与普通人群报道的成功率相当(>90%),但代价是并发症发生率较高(6%-20%)。精心规划适当的预防性抗生素使用和体位将使治疗效果最大化。
早期识别和治疗脊髓损伤患者的尿路结石将有助于保护肾功能并将相关并发症降至最低。尽管脊髓损伤治疗单位之间的常见泌尿外科操作存在差异,且缺乏明确的随访指南,但与尿路结石相关的风险发生率增加支持进行常规泌尿生殖系统影像学检查,以识别和治疗那些风险最高的个体。