Jones Alan L
Baylor University Medical Center at Dallas, Dallas, TX 75246-1800, USA.
J Orthop Trauma. 2005 Nov-Dec;19(10 Suppl):S23-5. doi: 10.1097/00005131-200511101-00007.
Recombinant human bone morphogenic protein-2 (rhBMP-2) is an osteoinductive protein that is now available for the acute treatment of open tibial fracture. Data from preclinical and clinical trials support its role in fracture care. This article summarizes data from two randomized controlled clinical trials investigating the safety and efficacy of rhBMP-2 in patients with open tibial shaft fractures and tibial fractures with bone defects. Also included is a summary of an economic analysis that examined the cost impact of rhBMP-2 from a hospital and payor perspective.
重组人骨形态发生蛋白-2（rhBMP-2）是一种骨诱导蛋白，目前可用于开放性胫骨骨折的急性治疗。临床前和临床试验数据支持其在骨折治疗中的作用。本文总结了两项随机对照临床试验的数据，这些试验研究了rhBMP-2在开放性胫骨干骨折和伴有骨缺损的胫骨骨折患者中的安全性和有效性。还包括一项经济分析的总结，该分析从医院和付款人的角度研究了rhBMP-2的成本影响。
