Recombinant human bone morphogenic protein-7: applications for clinical trauma.

Several clinical trials have examined the safety and efficacy of recombinant human bone morphogenic protein-7 (rhBMP-7) for osseous repair in clinical trauma. This article summarizes the results obtained from three recent clinical trials, which suggest that rhBMP-7 is useful in the treatment of tibial nonunion, long bone nonunion, and open tibial shaft fractures.