Ison Michael G, Gubareva Larisa V, Atmar Robert L, Treanor John, Hayden Frederick G
Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, 22908, USA.
J Infect Dis. 2006 Mar 15;193(6):760-4. doi: 10.1086/500465. Epub 2006 Feb 13.
Influenza virus with resistance to antiviral drugs emerges with increased frequency in immunocompromised patients and can limit the benefit of M2 and neuraminidase (NA) inhibitors. We document 3 cases of influenza in severely immunocompromised patients from whom virus variants with molecular markers of resistance to anti-influenza drugs were recovered. Virus variants recovered from 2 patients had mutations in the M2, NA (with a previously recognized Glu119Val NA substitution), and hemagglutinin genes. We describe a novel Asp198Asn NA mutation in an influenza B virus and its decreased susceptibility to both oseltamivir and zanamivir.
抗病毒药物耐药的流感病毒在免疫功能低下患者中出现的频率越来越高，这可能会限制M2抑制剂和神经氨酸酶（NA）抑制剂的疗效。我们记录了3例严重免疫功能低下患者的流感病例，从这些患者中分离出了具有抗流感药物耐药分子标记的病毒变体。从2例患者中分离出的病毒变体在M2、NA（具有先前确认的Glu119Val NA替换）和血凝素基因中发生了突变。我们描述了一种在乙型流感病毒中发现的新型Asp198Asn NA突变及其对奥司他韦和扎那米韦敏感性的降低。
