Saulnier N, Di Campli C, Zocco M A, Di Gioacchino G, Novi M, Gasbarrini A
Department of Medical Pathology, Catholic University of Rome, Italy.
Eur Rev Med Pharmacol Sci. 2005 Nov-Dec;9(6):315-24.
Adult stem cells (ASC) have becoming a great domain of research by their promising interest for the regenerative medicine. For some years, the number of publications has been increasing, displaying the potential of ASC to differentiate in all tissue-lineages, challenging the previous dogma that ASC were restricted to give rise only to specific cells from their tissue of origin. Among the diversity of ASC, hematopoietic stem cells (HSC) have been the most studied and their use in the clinical setting is largely documented. Commonly, HSC have been harvested from the bone marrow, but for some years, two others sources, the peripheral blood and the umbilical cord blood have been introduced. All these HSC posses their own molecular characteristics and degree of maturity and represent a more or less good candidate to participate in the cellular-based tissue regeneration. We have reviewed the different parameters allowing to define which subset could be the more favorable such as the accessibility to the pool of HSC; the quantity of available cells; the tolerability of host-engraftment and the capacity of the cells to home correctly to the required site of damaged. Besides, recently, the molecular profiling of HSC has allowed identifying which subset posses the more promising characteristics.
成体干细胞（ASC）因其在再生医学方面的潜在应用价值，已成为一个重要的研究领域。近年来，相关出版物数量不断增加，显示出ASC分化为所有组织谱系的潜力，这对之前认为ASC仅能分化为其起源组织特定细胞的教条提出了挑战。在ASC的多样性中，造血干细胞（HSC）研究最多，其在临床中的应用也有大量文献记载。通常，HSC是从骨髓中获取的，但近年来，另外两种来源，即外周血和脐带血也被引入。所有这些HSC都有其自身的分子特征和成熟程度，或多或少都是参与基于细胞的组织再生的良好候选者。我们回顾了不同的参数，这些参数有助于确定哪种亚群可能更有利，例如HSC库的可及性；可用细胞的数量；宿主植入的耐受性以及细胞正确归巢到受损所需部位的能力。此外，最近，HSC的分子谱分析已能够确定哪种亚群具有更有前景的特征。
