Schultz Iman J, Witjes J Alfred, Swinkels Dorine W, de Kok Jacques B
Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.
Clin Chim Acta. 2006 Jun;368(1-2):20-32. doi: 10.1016/j.cca.2005.12.036. Epub 2006 Feb 9.
Expression of the anti-apoptotic protein survivin is hardly detectable or even absent in many differentiated adult tissues, but is upregulated in almost any type of cancer. Furthermore, high survivin mRNA or protein expression generally correlates with an adverse disease course. Both these important features of survivin expression have been investigated for diagnostic and prognostic purposes in many human cancers, including bladder cancer. In this review, the role of survivin in the detection of bladder tumors and the prediction of tumor recurrence in patients with superficial bladder cancer will be discussed and compared to that of other markers/tests. The most promising marker(s) will be outlined. Also, important requirements for a successful implementation of such markers in a hospital setting are discussed. Finally, future directions for the discovery of new diagnostic or prognostic candidate markers will be mentioned.
抗凋亡蛋白survivin在许多分化成熟的成人组织中几乎检测不到甚至不存在，但在几乎任何类型的癌症中都会上调。此外，survivin mRNA或蛋白的高表达通常与不良的病程相关。survivin表达的这两个重要特征已在包括膀胱癌在内的许多人类癌症中进行了诊断和预后研究。在这篇综述中，将讨论survivin在浅表性膀胱癌患者膀胱肿瘤检测和肿瘤复发预测中的作用，并与其他标志物/检测方法进行比较。将概述最有前景的标志物。此外，还讨论了在医院环境中成功应用此类标志物的重要要求。最后，将提及发现新的诊断或预后候选标志物的未来方向。
