Doyle Robert L, Frazier Jean, Spencer Thomas J, Geller Daniel, Biederman Joseph, Wilens Timothy
Department of Psychiatry, Harvard Medical School, USA.
J Atten Disord. 2006 Feb;9(3):543-9. doi: 10.1177/1087054705284091.
Recent studies reported ADHD-like symptoms and cognitive deficits in pervasive developmental disorder (PDD). Because work in dementia documents improvement in executive function deficits with the acetylcholinesterase inhibitor donepezil, the authors reason that similar benefits could be obtained in PDD.
The authors describe eight cases of PDD youth ages 10 to 17 treated with donepezil targeting ADHD-like symptoms associated with PDD.
Most participants improve ADHD-like symptomatology. In addition, improvement in communication and socialization is noted.
Donepezil may have a role in treating ADHD-like symptoms in children with PDD.
近期研究报告了广泛性发育障碍（PDD）中存在类似注意力缺陷多动障碍（ADHD）的症状和认知缺陷。由于针对痴呆症的研究表明，乙酰胆碱酯酶抑制剂多奈哌齐可改善执行功能缺陷，作者据此推断，在PDD中可能也能获得类似的益处。
作者描述了8例年龄在10至17岁的PDD青少年，他们接受了多奈哌齐治疗，以针对与PDD相关的类似ADHD的症状。
大多数参与者的类似ADHD的症状有所改善。此外，还注意到沟通和社交能力有所改善。
多奈哌齐可能在治疗PDD儿童的类似ADHD症状方面发挥作用。
