Morita H, Ishiki K, Hosomi H
Department of Physiology, Kagawa Medical School, Japan.
Neurosci Lett. 1991 Feb 11;123(1):1-3. doi: 10.1016/0304-3940(91)90143-h.
The effects of intrahepatic NaCl or osmo-receptor stimulation on renal nerve activity were examined in chronically instrumented conscious rabbits. Combined infusions of 9% NaCl via the portal vein and distilled water via the inferior vena cava did not alter plasma osmolality or plasma Na concentration of the systemic circulation but decreased renal nerve activity. Combined infusion of 6.5% LiCl and distilled water did not have any effects on renal nerve activity. The decrease in renal nerve activity induced by portal 9% NaCl infusions was completely abolished after section of the anterior and posterior hepatic nerves. These results indicate that stimulation of the intrahepatic NaCl receptors, not of the osmoreceptors, elicits a reflex decrease in renal nerve activity, which is mainly mediated by the anterior and posterior hepatic nerves.
在长期植入仪器的清醒家兔中，研究了肝内氯化钠或渗透压感受器刺激对肾神经活动的影响。经门静脉联合输注9%氯化钠和经下腔静脉联合输注蒸馏水，并未改变体循环的血浆渗透压或血浆钠浓度，但降低了肾神经活动。联合输注6.5%氯化锂和蒸馏水对肾神经活动没有任何影响。切断肝前神经和肝后神经后，门静脉输注9%氯化钠所诱导的肾神经活动降低完全被消除。这些结果表明，刺激肝内氯化钠受体而非渗透压感受器，会引起肾神经活动反射性降低，这主要由肝前神经和肝后神经介导。
