Morita H, Ohyama H, Hagiike M, Horiba T, Miyake K, Yamanouchi H, Matsushita K, Hosomi H
Department of Physiology, Kagawa Medical School, Japan.
Am J Physiol. 1990 Dec;259(6 Pt 2):R1289-94. doi: 10.1152/ajpregu.1990.259.6.R1289.
Jejunal electrolyte absorption was measured in the jejunal loops of anesthetized dogs during infusions of hypertonic solutions via the portal vein. The net Na absorption was not influenced by the 9% NaCl infusion into the inferior vena cava, although it was significantly attenuated by the portal 9% NaCl infusion. This effect may not be due to the osmotic stimulus, since the portal 50% glucose or 6.5% LiCl infusion had no significant influence on the net Na absorption. To determine the mechanism of the decrease in the net Na absorption during the portal hypertonic NaCl infusion, the net Na absorption was measured after the section of anterior and posterior hepatic nerves (SAPH) or intravenous atropine injection. Both SAPH and the intravenous atropine injection completely blocked the effect of the portal 9% NaCl infusion on the net Na absorption. These results indicate that 1) net Na absorption in dog jejunum is depressed by the hypertonic NaCl infusion via the portal vein; 2) the effect is NaCl specific and may not be due to the osmotic stimulus; and 3) the afferent limbs of this effect are the anterior and posterior hepatic nerves, and the efferent limb of this effect is the vagus nerve. Thus the hepatojejunal reflex may play an important role in the regulation of body fluid homeostasis.
在通过门静脉输注高渗溶液期间，对麻醉犬的空肠袢进行空肠电解质吸收测量。尽管门静脉输注9%氯化钠会显著减弱净钠吸收，但下腔静脉输注9%氯化钠对净钠吸收没有影响。这种效应可能不是由于渗透压刺激，因为门静脉输注50%葡萄糖或6.5%氯化锂对净钠吸收没有显著影响。为了确定门静脉高渗氯化钠输注期间净钠吸收减少的机制，在切断肝前和肝后神经（SAPH）或静脉注射阿托品后测量净钠吸收。切断肝前和肝后神经以及静脉注射阿托品均完全阻断了门静脉输注9%氯化钠对净钠吸收的影响。这些结果表明：1）门静脉输注高渗氯化钠会抑制犬空肠的净钠吸收；2）该效应具有氯化钠特异性，可能不是由于渗透压刺激；3）该效应的传入神经是肝前和肝后神经，传出神经是迷走神经。因此，肝空肠反射可能在体液稳态调节中起重要作用。
