施佩曼组织者与两栖类胚胎的自我调节
Spemann's organizer and self-regulation in amphibian embryos.
作者信息
De Robertis Edward M
机构信息
Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, California 90095-1662, USA.
出版信息
Nat Rev Mol Cell Biol. 2006 Apr;7(4):296-302. doi: 10.1038/nrm1855.
Abstract
In 1924, Spemann and Mangold demonstrated the induction of Siamese twins in transplantation experiments with salamander eggs. Recent work in amphibian embryos has followed their lead and uncovered that cells in signalling centres that are located at the dorsal and ventral poles of the gastrula embryo communicate with each other through a network of secreted growth-factor antagonists, a protease that degrades them, a protease inhibitor and bone-morphogenic-protein signals.
摘要
1924年，施佩曼和曼戈尔德在蝾螈卵移植实验中证明了联体双胎的诱导现象。近期对两栖动物胚胎的研究追随了他们的脚步，并发现原肠胚胚胎背腹两极信号中心的细胞通过一个由分泌型生长因子拮抗剂、降解这些拮抗剂的蛋白酶、一种蛋白酶抑制剂以及骨形态发生蛋白信号组成的网络相互通讯。
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