Bansinath M, Ramabadran K, Turndorf H, Puig M M
Department of Anesthesiology, School of Medicine, New York University Medical Center, N.Y.
Pharmacology. 1991;42(2):97-102. doi: 10.1159/000138779.
The effects of kappa-opiate agonists on gastrointestinal motility was assessed in Swiss Webster, C57BL/6, BALB/c and DBA/2 strains of mice. The kappa-agonists, PD 117302, U-69593 and U-50488H (3 mg kg-1), were injected subcutaneously and the distance travelled by a charcoal meal in the gastrointestinal tract was measured. All kappa-agonists induced significant inhibition of charcoal meal transit; however, there were significant strain differences in the antitransit effect. It is concluded that kappa-receptors are involved in the inhibition of gastrointestinal transit and that the negative data reported in the literature may be due to a genotype-dependent effect of kappa-agonists.
在瑞士韦伯斯特、C57BL/6、BALB/c和DBA/2品系小鼠中评估了κ-阿片受体激动剂对胃肠动力的影响。皮下注射κ-激动剂PD 117302、U-69593和U-50488H（3 mg kg-1），并测量炭末在胃肠道中的移动距离。所有κ-激动剂均显著抑制炭末转运；然而，在抗转运作用方面存在显著的品系差异。得出的结论是，κ-受体参与胃肠转运的抑制，文献中报道的阴性数据可能归因于κ-激动剂的基因型依赖性效应。
